Nucleic Acid Drug Delivery Platforms
Lipid nanoparticles (LNPs) are advanced carriers that protect and deliver nucleic‑acid therapeutics to their intended site of action. Their design determines whether a therapy reaches the right cells, achieves efficient expression, and maintains a strong safety profile. At etherna, we treat design as a tailored engineering process, not a one‑size‑fits‑all solution.
Using proprietary ionizable lipid libraries and advanced conjugation strategies, we create LNPs that match the specific needs of each payload, indication, and route of administration. This enables precise control over targeting, biodistribution, and overall performance.
How We Engineer Fit-for-Purpose LNPs!
Customized LNPs are key to advancing nucleic-acid-based medicines for both prophylactic and therapeutic use.
We have built deep expertise and a dedicated experimental framework to design and optimize LNPs for specific
therapeutic applications.
Ionizable Lipid
Our proprietary ionizable lipid library comprises more than 2,500 distinct lipids, enables precise tuning of delivery systems, including intrinsic liver de-targeting capabilities.
Conjugation Strategy
We apply advanced conjugation strategies to engineer targeted lipid nanoparticles (LNPs), using site-specific methods such as VHH nanobody conjugation to enhance targeting activity and achieve highly selective receptor binding.
Versatile Payload
Our platform is designed to support the encapsulation of a wide range of nucleic acid payloads. With deep expertise across multiple cargo types, including pDNA, mcDNA, circRNA, siRNA, and small ASOs, we ensure flexibility across diverse therapeutic applications.
Optimized LNPs
To further optimize performance, we tailor LNP compositions to the intended application, maximizing activity while maintaining a strong safety profile.
PEG Alternatives
We actively develop and evaluate PEG alternatives through proprietary, bio-inspired polymer-lipid conjugates, improving LNP stability both during storage and in vivo delivery.
Our LNP platforms are differentiated by their targeting properties, biodistribution profiles, and payload compatibility, providing tailored solutions for diverse nucleic‑acid modalities.
IV delivery
Genetic diseases &
Gene editing
Targeted LNP delivery engineered for efficient in vivo gene editing in Hematopoietic stem cells
IV delivery
Immuno-oncology &
Autoimmune diseases
Precision LNP delivery enabling ex vivo and in vivo T‑cell reprogramming for immuno‑oncology and autoimmune applications
IV Delivery
Liver diseases, secreted factors & Gene editing
Clinically aligned LNP delivery optimized for durable hepatic expression and repeat dosing
IV delivery
Tolerizing vaccine for autoimmune diseases
Immune‑silent LNPs designed to induce antigen‑specific immune tolerance in autoimmune disease
IM delivery
Infectious diseases
Prophylactic vaccine
Immune‑stimulatory LNP platform optimized for intramuscular vaccine delivery and robust antibody responses
IT delivery
Intratumoral immunomodulation Immuno-oncology
Localized intratumoral LNP delivery platform for targeted immune activation in cancer
“We combine deep scientific expertise, tailored engineering, and world‑class manufacturing to accelerate the development of high‑performing LNPs.”
Comprehensive
Our diverse portfolio of LNP formulations supports a wide spectrum of therapeutic applications from prophylactic and cancer vaccines to gene therapy, protein replacement, and beyond. This breadth allows partners to select the optimal delivery system for their modality and target tissue.
Customizable
We engineer LNPs with precision. Leveraging proprietary ionizable lipid libraries, specialized conjugation strategies, and an advanced experimental framework, we develop fit‑for‑purpose LNPs tailored to each payload, indication, and route of administration.
World Class facilities
Our state‑of‑the‑art LNP manufacturing sites in Ghent and Niel, Belgium, support the seamless transition from research to production. We deliver high‑quality LNPs for preclinical studies and scale up to GMP‑ready processes, ensuring quality, reliability and consistency at every stage.
Contact us with any queries or for pricing information.