mRNA platform
Our mRNA platforms and vast in-house experience help partners quickly optimize, screen and select an mRNA code, develop a candidate, and ensure effective & prime manufacturing of the mRNA from research grade to GMP scale. Our platform’s scale and flexibility is uniquely suited to respond to the needs of development partners across a wide range of therapeutic applications.
Sequence Optimization
- Sequence optimization algorithms to increase the translation efficiency of the gene of interest by changing compatible codons
- 5’ and 3’ UTRs optimized for expression in human dendritic cells and myocytes
- C- terminal endosomal sorting signal demonstrated to enhance antigen presentation to CD4 and CD8 T cells
- High throughput screening of our in-house library of UTRs to find the best combination for maximized expression in your cell type of interest
Highly pure RNA
- Proprietary mRNA production processes (IVT and purification) optimized for increased purity and, as such, decrease impurity related immunogenicity and toxicity, allowing increased translation efficiency
mRNA based
immune-stimulants
- One type of mix is a combination of 3 or 4 mRNAs enhancing T-cell responses to mRNA encoded cancer antigens (TriMix and TetraMix). TriMix has been validated in multiple clinical studies
- We also developed a proprietary mix of mRNAs encoding for signaling proteins that modulate the tumor microenvironment after intratumoral administration which enables the induction of an anti-tumor response
Struggling with lack of internal expertise for your RNA therapeutics project or have multiple development needs? Our 30 years of experience and comprehensive platform offering can help.
Pioneering expertise
Integrated offering
Flexible partnership
Europe GMP facilities
“I’m very happy to let you know that the FDA informed us that our IND was cleared! We do expect non-hold questions in the next few weeks. We thank you so much for your great contribution!”
Versameb“etherna’s eGFP gives 3x higher expression than all others previously tested”
Karolinska Institute“I am writing to you following the experiments we performed using the GFP mRNA received from eTheRNA….. we found it to be an excellent cargo in-vitro in comparison to others”
Dan Peer“….we have now conducted our investigational experiments and I can confirm that your mRNA performed wonderfully!”
Resolution Tx“…we are very confident on ETheRNA performance. All good so far!”
Scripps“…It has certainly been a very pleasant experience so far…”
Diosynvax“I have very much enjoyed working with the team at eTheRNA. I’ve been impressed with the quality of the work and the responsiveness of the team” – etherna’s mRNA is superior to that of Aldevron
HDT BioContact us with any queries or for pricing information.