// manufacturing

Manufacturing

eTheRNA builds on over 30 years of research grade mRNA manufacturing, and more than 5 years of GMP mRNA production. The initial experience was gained at the labs of the VUB in Brussels. Since 2018, all RNA production has been performed in the brand new GMP authorized facility in Niel, Belgium.

// Manufacturing

Plasmid DNA

eTheRNA has extensive experience in the design and production of plasmid DNA (pDNA) for RNA transcription and has developed a standardized approach to produce the best in class plasmids for your projects.

Specifications:

  • Concentration
  • Homogenicity
  • Identity
  • Endotoxin content
  • Bioburden
// manufacturing

Research Grade RNA

We can manufacture the following RNA types by in vitro transcription:

  • mRNA
  • Long RNA
  • Guide RNA

with sizes from about 200 to 10000 nt

The RNA can be made by using regular or modified NTP’s, and with different cap-analogs (CAP1, CAP0).

Specifications:

  • Concentration
  • Integrity
// Manufacturing

GMP Grade RNA

We can manufacture the following RNA types by in vitro transcription:

  • mRNA
  • Long RNA
  • Guide RNA

with sizes from about 200 to 10000 nt

The RNA can be made by using regular or modified NTP’s, and with different cap-analogs.

Specifications:

  • Visual inspection
  • Appearance
  • Integrity
  • Identity
  • pDNA content
  • Protein content
  • Endotoxin content
  • Concentration
  • Potency
  • Sterility
  • RNA sequence
// Manufacturing

Services

Validation & Verification

Validation and verification of processes and methods

Inbound technology transfer 

Technology transfer of your developed processes to our facilities to prepare for upscaling

Stability studies

Stability studies in different conditions on API, IMP or reconstitution buffers

Supply of reconstitution buffers

Storage of inventory at 15-25°C, 2-8°C, -15°C

Storage of WCD at –80°C

Development activities

  • Process development
  • Purification development
  • Analytical method development
  • Upscaling

Galileilaan 19, 2845 Niel, Belgium

Our Address

Our Mailbox

+32 3 369 17 40

Our Phone

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