eTheRNA immunotherapies is driving mRNA technology and therapeutic product development to deliver an innovative generation of RNA chemistries, RNA process technologies and a new and advanced generation of therapeutic and vaccine products. eTheRNA uses its established R&D foundations and in-house GMP manufacturing facilities and builds on its proprietary mRNA, mRNA adjuvant and mRNA formulation platforms to progress technology innovation and product development.
eTheRNA was established in January 2013 as a spin-off company from the ‘Vrije Universiteit Brussel’ (VUB), following the development of its TriMix mRNA technology.
eTheRNA’s TriMix contains three naked mRNA molecules that combined work as a potent T-cell vaccine adjuvant:
TriMix is unique in the way it uses these three mRNA molecules to induce the proliferation of T-cells into either mature helper T-cells or cytotoxic T-cells – the ultimate ‘soldiers’ of the immune system that fight cancer cells and infectious agents. By combining TriMix with tumor-specific antigens or neoantigens the patient’s dendritic cells are stimulated to produce a more potent and larger population of antigen specific cytotoxic and helper T-cells compared to tumor antigens alone.
eTheRNA LNPs for intravenous delivery of mRNA have been show to exert first-in-class immune T-cell-specific responses in preclinical experiments. The induced immune responses are multifunctional and boostable. These premium results was achieved by optimizing the composition of the LNPs and designing them to target the spleen and not mainly the liver.
Generally speaking, R&D grade RNA can be ordered from amounts as small as 1mg up to gram amounts. GMP grade production usually starts at higher quantities, preferably starting at around 100mg up to gram range. Very small or very large batches may restrict the options for purification.
eTheRNA distinguishes itself from competitors on different levels:
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